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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN12
All Species:
18.18
Human Site:
S435
Identified Species:
40
UniProt:
Q05209
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05209
NP_001124480.1
780
88120
S435
K
K
L
E
R
N
L
S
F
E
I
K
K
V
P
Chimpanzee
Pan troglodytes
XP_519168
792
88529
S447
K
K
L
E
R
N
L
S
F
E
I
K
K
V
P
Rhesus Macaque
Macaca mulatta
XP_001082837
733
82786
H394
Y
H
P
K
P
V
L
H
M
V
S
S
E
Q
H
Dog
Lupus familis
XP_540396
757
85032
S410
K
K
L
E
R
N
L
S
F
E
I
K
K
V
P
Cat
Felis silvestris
Mouse
Mus musculus
P35831
775
86973
S434
K
K
L
E
R
N
L
S
F
E
I
K
K
V
P
Rat
Rattus norvegicus
NP_476456
766
85965
K427
S
A
V
E
H
T
D
K
K
L
E
Q
N
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507461
747
83881
E407
E
R
L
E
K
K
L
E
R
N
L
S
F
E
I
Chicken
Gallus gallus
XP_415970
1211
131521
S856
K
R
L
E
R
N
L
S
F
E
I
R
K
V
P
Frog
Xenopus laevis
NP_001084841
660
74123
P321
N
N
I
D
D
N
I
P
S
E
N
E
K
T
D
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
G231
I
C
V
H
C
S
A
G
C
G
R
T
G
A
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
P468
T
S
V
V
L
T
K
P
K
P
G
Q
A
V
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
91.4
88
N.A.
82.8
83.5
N.A.
74.6
48.3
58.2
46.7
N.A.
N.A.
N.A.
N.A.
28.9
Protein Similarity:
100
95.4
92.3
91
N.A.
88.3
88.8
N.A.
81.1
53.5
66.9
57.4
N.A.
N.A.
N.A.
N.A.
44
P-Site Identity:
100
100
6.6
100
N.A.
100
6.6
N.A.
20
86.6
20
0
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
20
100
N.A.
100
26.6
N.A.
46.6
100
46.6
13.3
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
10
0
0
0
0
0
10
10
0
% A
% Cys:
0
10
0
0
10
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
10
0
10
0
0
0
0
0
0
0
10
% D
% Glu:
10
0
0
64
0
0
0
10
0
55
10
10
10
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
46
0
0
0
10
0
0
% F
% Gly:
0
0
0
0
0
0
0
10
0
10
10
0
10
0
0
% G
% His:
0
10
0
10
10
0
0
10
0
0
0
0
0
0
10
% H
% Ile:
10
0
10
0
0
0
10
0
0
0
46
0
0
0
19
% I
% Lys:
46
37
0
10
10
10
10
10
19
0
0
37
55
0
10
% K
% Leu:
0
0
55
0
10
0
64
0
0
10
10
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
10
10
0
0
0
55
0
0
0
10
10
0
10
0
0
% N
% Pro:
0
0
10
0
10
0
0
19
0
10
0
0
0
0
46
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
19
0
10
0
% Q
% Arg:
0
19
0
0
46
0
0
0
10
0
10
10
0
0
0
% R
% Ser:
10
10
0
0
0
10
0
46
10
0
10
19
0
0
10
% S
% Thr:
10
0
0
0
0
19
0
0
0
0
0
10
0
10
0
% T
% Val:
0
0
28
10
0
10
0
0
0
10
0
0
0
55
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _